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Digestion/Heart

Artichoke extract

Concentrated leaf extract used to relieve indigestion and bloating, with modest evidence for lowering LDL cholesterol in adults.

Artichoke extract
54
score
B
evidence
Caution
risk

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Use with caution

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Quick Take

Worth considering for dyspepsia or IBS; modest cholesterol benefit. Skip if you have gallstones.

Artichoke extract is a concentrated form of the globe artichoke leaf, rich in caffeoylquinic acids and flavonoids like luteolin. It is traditionally used as a digestive bitter to stimulate bile flow and support liver function. Clinical trials suggest it can reduce symptoms of functional dyspepsia and irritable bowel syndrome, and may lower total and LDL cholesterol by inhibiting cholesterol synthesis. Adults with chronic bloating, post-meal discomfort, or mild hyperlipidemia are most likely to notice benefit.

Potential benefits

01
Relieves functional dyspepsia
02
Lowers LDL cholesterol
03
May reduce IBS symptoms
04
May lower blood pressure
05
May lower triglycerides

Protocol

Amount
600-1800 mg
Frequency
Split into 2-3 doses daily
When
With meals to enhance digestive bile stimulation and reduce stomach upset.

Onset Time

Digestive relief within 1-2 weeks; lipid changes in 6-12 weeks.

Who Should Consider

People with functional dyspepsia or IBS
Adults with mild LDL elevation
Those with frequent post-meal bloating
People seeking digestive bitters

Food Sources

  • Fresh globe artichoke hearts (~100g) — low active concentration
  • Artichoke leaf tea — variable polyphenol content

How It Works

The active compounds, particularly chlorogenic acid and luteolin, stimulate bile secretion and flow from the liver, aiding fat digestion and reducing gut fermentation. They also inhibit HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase, modestly reducing endogenous cholesterol production and intestinal cholesterol absorption.

Updated 5/19/2026

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