Hormonal

Calcium D-Glucarate

Calcium salt of D-glucaric acid that may lower beta-glucuronidase and support estrogen metabolism in adults with elevated estrogen recirculation.

score

evidence

Caution

risk

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Use with caution

This supplement may interact with medications, medical conditions or sensitive populations. Review safety before use.

Overview

Forms

Safety

Stack

Quick Take

Niche use only: may help estrogen metabolism markers, but human evidence remains preliminary.

Calcium D-glucarate is the calcium salt of D-glucaric acid, a compound found in cruciferous vegetables and citrus fruits. In the body it can form D-glucaro-1,4-lactone, which inhibits beta-glucuronidase. That may help keep estrogens and other glucuronidated compounds excreted rather than recycled in the gut. Small human studies suggest modest changes in beta-glucuronidase activity and estrogen metabolite patterns. It is mainly considered by people focused on estrogen metabolism.

Potential benefits

May lower beta-glucuronidase

May shift estrogen metabolite profi

Protocol

Amount

500-1500 mg

Frequency

Once daily; split higher daily doses if needed for tolerance.

When

With meals; larger daily doses are often split to improve tolerance.

Onset Time

2-4 weeks for biomarker changes; symptom changes are less predictable.

Who Should Consider

Adults with elevated estrogen recirculation

People with elevated beta-glucuronidase

Those eating few cruciferous vegetables

Adults tracking urinary estrogen metabolites

How It Works

Once ingested, calcium D-glucarate is converted to D-glucaro-1,4-lactone, an inhibitor of beta-glucuronidase. Lower beta-glucuronidase can reduce deconjugation of glucuronidated hormones in the intestine and may reduce enterohepatic recycling.

Updated 5/19/2026