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Heart/Inflammation/Beauty

Grape Seed Extract

Antioxidant-rich extract from grape seeds studied for blood pressure, cholesterol, and skin resilience in adults with metabolic risk factors.

Grape Seed Extract
48
score
C
evidence
Caution
risk

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Quick Take

Small benefits for blood pressure and LDL, but evidence is mixed and effects are modest.

Grape seed extract is a concentrated polyphenol supplement made from Vitis vinifera seeds; related proanthocyanidins are also found in grape skins, red wine, cocoa, and some berries. It acts mainly as an antioxidant and may support nitric oxide signaling and endothelial function. The best-supported benefits are small reductions in blood pressure, possible modest LDL lowering, and possible relief of chronic venous symptoms; there is also limited evidence for skin photoprotection. Adults with elevated blood pressure, dyslipidemia, or venous insufficiency are most likely to notice a benefit.

Potential benefits

01
Lowers blood pressure
02
May reduce LDL cholesterol
03
May ease venous symptoms
04
May improve endothelial function
05
May lower CRP and oxidative stress
06
May protect skin from UV damage

Protocol

Amount
150-400 mg
Frequency
Once daily
When
With a meal to improve absorption and reduce stomach upset.

Onset Time

8-12 weeks for blood pressure and lipid changes; skin effects may take 12+.

Who Should Consider

Adults with elevated blood pressure
People with elevated LDL cholesterol
People with chronic venous insufficiency
Adults concerned about skin photoaging

How It Works

The active proanthocyanidins act as free-radical scavengers and may protect vascular endothelium by reducing oxidative stress and improving nitric oxide bioavailability. They also appear to inhibit LDL oxidation and modulate inflammatory signaling pathways, though the clinical relevance of these mechanisms in humans remains uncertain.

Updated 5/19/2026

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