Performance/Weight

Laxogenin

Plant-derived brassinosteroid analog marketed for muscle growth, but human evidence is too limited to show reliable benefits in adults.

score

evidence

Caution

risk

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Use with caution

This supplement may interact with medications, medical conditions or sensitive populations. Review safety before use.

Overview

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Safety

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Quick Take

Skip it — no reliable human trials show meaningful benefits, and long-term safety is unclear.

Laxogenin is a plant-derived sapogenin related to brassinosteroids and is often sold as a 'natural anabolic'; it has no meaningful food-source use. Cell and animal studies suggest it may influence PI3K/Akt/mTOR signaling and protein turnover, but these mechanisms have not been confirmed in humans. Human evidence for muscle gain, strength, or body-composition change is essentially absent. It is mainly marketed to gym users, but the average health-conscious adult is unlikely to benefit.

Potential benefits

May support lean body mass

May improve strength output

May aid exercise recovery

Protocol

Amount

100-200 mg

Frequency

Once daily

When

Any time of day — timing is unstudied, so consistency matters more than timing.

Onset Time

Unknown in humans; any body-composition claim would likely require weeks.

Who Should Consider

People should generally not prioritize this supplement

Adults willing to avoid poorly studied 'anabolic' products

How It Works

Preclinical studies suggest laxogenin may upregulate PI3K/Akt/mTOR signaling and reduce protein breakdown, which could theoretically favor muscle protein synthesis. These findings come from non-human models and have not been shown to translate into measurable human outcomes.

Updated 5/19/2026