Cognition/Mood/Immunity

Lion's Mane

Medicinal mushroom studied for mild cognitive impairment and mood support in adults, with preliminary human trial data.

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Quick Take

Worth considering for memory or mood concerns; evidence is early but consistently positive in small trials.

Lion's mane is an edible medicinal mushroom native to North America, Europe, and Asia. It contains bioactive compounds called hericenones and erinacines that may stimulate nerve growth factor synthesis and support neuronal health. Human trials suggest it may improve cognitive function in older adults with mild cognitive impairment and reduce symptoms of anxiety and depression. People seeking cognitive support or mood balance, particularly those in middle age and beyond, are most likely to benefit.

Potential benefits

Improves cognitive function

May reduce anxiety and depression

May support immune function

Protocol

Amount

500-3000 mg

Frequency

Once daily, or split into two doses

When

With food to improve absorption and reduce GI upset.

Onset Time

4-8 weeks for cognitive and mood effects.

Who Should Consider

Adults 50+ with mild memory concerns

People with elevated anxiety or low mood

Students seeking cognitive support

Those interested in neuroprotective supplements

How It Works

Hericenones and erinacines cross the blood-brain barrier and stimulate synthesis of nerve growth factor (NGF), which supports neuronal maintenance and plasticity. Polysaccharides in the fruiting body may also modulate immune cell activity and cytokine production.

Updated 5/19/2026