Skip to content
Mobility/Inflammation/Beauty

MSM

Organic sulfur compound studied for joint comfort, skin aging, and inflammatory markers in adults with mild osteoarthritis.

MSM
52
score
C
evidence
Safe
risk

Our methodology: How we evaluate supplements and turn the underlying research into a single rating.

Read full methodology
Quick Take

Modest help for knee osteoarthritis; weak evidence for skin aging and inflammation.

MSM is an organosulfur compound found in small amounts in plants, animals, and foods such as coffee and milk. It serves as a source of bioavailable sulfur for collagen, cartilage, and glutathione synthesis. Clinical trials suggest modest improvements in knee osteoarthritis pain and function, possible benefits for skin hydration and wrinkle appearance, and small reductions in inflammatory markers. It is most useful for adults with mild joint discomfort or skin aging concerns.

Potential benefits

01
Improves knee pain/function
02
May lower inflammatory markers
03
May improve skin aging

Protocol

Amount
1500-3000 mg
Frequency
Divided into 2-3 doses daily
When
With meals to minimize gastrointestinal upset.

Onset Time

4-12 weeks for joint pain; 8-16 weeks for skin benefits.

Who Should Consider

Adults with knee osteoarthritis
People with mild joint stiffness
Adults concerned with skin aging
Those with elevated inflammatory markers

How It Works

MSM donates sulfur for the synthesis of collagen, cartilage, and the antioxidant glutathione. It appears to attenuate NF-κB signaling and reduce pro-inflammatory cytokines such as TNF-α and IL-6, which may explain modest improvements in joint discomfort and inflammatory markers.

Updated 5/19/2026

Put MSM in context.

Compare the closest evidence-ranked options, or see how this supplement fits your goals and what you already take.

Is MSM right for your goals?

Answer four quick questions for recommendations that already account for the supplement you just reviewed.

Get recommendations