Hormonal/Weight/Cognition

Yohimbine

Alpha-2 adrenergic antagonist sometimes used for erectile dysfunction and fat loss, but with significant safety concerns and mixed evidence.

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evidence

Unsafe

risk

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Significant safety concern

This supplement has a significant safety concern and should be avoided unless medically supervised.

Overview

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Safety

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Quick Take

Skip unless prescribed; modest benefits for ED and fat loss are outweighed by anxiety and cardiovascular risks.

Yohimbine is an indole alkaloid derived from the bark of the African Pausinystalia yohimbe tree. It acts primarily as an alpha-2 adrenergic receptor antagonist, increasing norepinephrine release and sympathetic tone. It has been studied in small clinical trials for psychogenic erectile dysfunction and body fat reduction, though evidence is inconsistent and largely superseded by safer alternatives. Some preliminary research suggests effects on sexual arousal in women and acute alertness. Due to its stimulant and hypertensive properties, it carries meaningful risks even at standard doses.

Potential benefits

May improve erectile function

May reduce body fat

May increase sexual arousal

May increase acute alertness

Protocol

Amount

5-10 mg per dose

Frequency

Up to 3x daily (ED); single morning dose (fat loss)

When

On an empty stomach; avoid late-day dosing due to stimulant effects

Onset Time

Acute, within 30-90 minutes

Who Should Consider

Men with psychogenic ED under medical supervision

Individuals in fasted exercise protocols under supervision

How It Works

Yohimbine blocks alpha-2 adrenergic receptors on presynaptic nerve terminals, disinhibiting norepinephrine release and increasing sympathetic nervous system activity. This raises heart rate and blood pressure and may increase penile blood flow via neural pathways.

Updated 5/19/2026