Sleep/Mood

Apigenin

Plant flavonoid from chamomile and parsley studied for mild calming and anti-inflammatory effects, mainly for sleep and relaxation.

score

evidence

Caution

risk

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Use with caution

This supplement may interact with medications, medical conditions or sensitive populations. Review safety before use.

Overview

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Safety

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Quick Take

Direct human evidence is limited; may help sleep and relaxation, but most support comes from chamomile trials.

Apigenin is a flavone found in chamomile, parsley, celery, and some citrus fruits. It may calm the nervous system by modulating GABA_A signaling and shows anti-inflammatory activity in lab studies. The best human evidence comes from chamomile extract trials, which suggest modest benefits for sleep quality and anxiety. It is most relevant for people with mild sleep problems or stress who want a non-prescription calming aid.

Potential benefits

May improve sleep quality

May reduce anxiety

Protocol

Amount

50 mg

Frequency

Once daily

When

Evening, 30-60 minutes before bed; may take with a small amount of fat.

Onset Time

1-2 hours for acute relaxation; 2-4 weeks for sleep quality.

Who Should Consider

Adults with mild stress-related sleep difficulty

People seeking non-prescription relaxation aids

Those with low dietary flavonoid intake

Individuals interested in chamomile's active compound

How It Works

Apigenin can cross the blood-brain barrier and modestly modulate GABA_A receptors, including the benzodiazepine binding site, which may reduce neural excitability. In lab studies it also inhibits NF-κB and COX-2 signaling, producing anti-inflammatory effects that are not yet well proven in humans.

Updated 5/19/2026