Inflammation/Mobility/Digestion

Bromelain

Proteolytic enzyme from pineapple stems that may reduce post-operative swelling and sinus inflammation, and help with osteoarthritis pain.

score

evidence

Caution

risk

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Use with caution

This supplement may interact with medications, medical conditions or sensitive populations. Review safety before use.

Overview

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Safety

Stack

Quick Take

Worth trying for sinus issues or post-op swelling; limited value as a general supplement.

Bromelain is a mixture of proteolytic enzymes extracted from pineapple stems and fruit (Ananas comosus). It is found in pineapple, especially the stem and core, but supplements provide much higher enzyme activity than food. Bromelain has anti-inflammatory, anti-edema, and fibrinolytic actions, and may also help break down dietary protein. Human trials suggest modest benefits for post-operative swelling, sinus symptoms, osteoarthritis pain, and protein digestion.

Potential benefits

Reduces post-operative swelling

Improves osteoarthritis pain

Reduces sinusitis symptoms

May lower inflammation

May aid protein digestion

May reduce allergy symptoms

Protocol

Amount

500-1000 mg

Frequency

2-3 times daily

When

On an empty stomach for anti-inflammatory effects; with meals if used as a digestive aid.

Onset Time

Hours for digestion; 3-7 days for swelling/pain.

Who Should Consider

Adults recovering from dental or nasal surgery

People with chronic sinusitis or allergic rhinitis

Adults with mild osteoarthritis

People who want digestive enzyme support

How It Works

Bromelain proteases can reduce fibrin deposition and may alter prostaglandin and bradykinin signaling, which can limit swelling. As a protease, it can also hydrolyze dietary proteins in the gastrointestinal tract when taken with food.

Updated 5/19/2026