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Inflammation/Mobility/Heart

Curcumin

Turmeric polyphenol with anti-inflammatory effects that may ease joint discomfort and modestly improve cardiometabolic markers.

Curcumin
50
score
C
evidence
Caution
risk

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This supplement may interact with medications, medical conditions or sensitive populations. Review safety before use.

Quick Take

Most worth trying in a high-absorption form for joint pain; plain curcumin capsules are often underdosed and poorly absorbed.

Curcumin is the main polyphenol in turmeric root (Curcuma longa), used in curry powders and golden milk. It influences inflammatory pathways such as NF-κB and COX-2 and has antioxidant effects, but plain curcumin is absorbed poorly unless formulated. Best-supported benefits are modest reductions in osteoarthritis pain, some lowering of inflammatory markers, and possible small improvements in glucose or lipid markers. Adults with joint discomfort or low-grade inflammation are most likely to notice a benefit.

Potential benefits

01
Improves OA pain/function
02
Lowers CRP/inflammatory markers
03
May improve glucose control
04
May reduce depressive symptoms
05
May improve lipids/BP
06
May aid colitis remission
07
May improve memory/attention
08
May reduce skin inflammation

Protocol

Amount
500-1000 mg curcuminoids
Frequency
Once or twice daily
When
With a meal containing fat; if the product uses piperine, check medication interactions first.

Onset Time

2-8 weeks for joint symptoms; 8-12 weeks for lab markers

Who Should Consider

Adults 40+ with mild knee or joint discomfort
People with elevated hs-CRP or low-grade inflammation
Adults with mildly elevated glucose or lipid markers
People choosing a non-NSAID joint support trial

Food Sources

  • Ground turmeric (~50-150 mg curcuminoids per tsp, highly variable)
  • Fresh turmeric root (less concentrated than extracts)
  • Curry powder blends (small, variable amounts of turmeric)

How It Works

Curcumin downregulates inflammatory signaling pathways including NF-κB and COX-2, which can reduce production of markers such as CRP, IL-6, and TNF-α. It is poorly water-soluble and rapidly metabolized, so delivery form strongly affects how much reaches the bloodstream.

Updated 5/19/2026

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