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Longevity

Fisetin

Flavonoid from strawberries and other fruits studied as a senolytic to clear aging cells and reduce inflammation; human evidence is limited.

Fisetin
28
score
D
evidence
Caution
risk

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Quick Take

Experimental only; human evidence is very limited and long-term effects are unknown.

Fisetin is a flavonol found in strawberries, apples, persimmons, onions, and cucumbers. In cells and animals it can dampen NF-κB signaling, lower oxidative stress, and promote clearance of senescent cells. Human research is still small and preliminary, but it is being studied for effects on senescence markers, inflammation, and age-related function in older adults. Most people should view it as an experimental longevity compound rather than a proven daily supplement.

Potential benefits

01
May reduce senescence markers
02
May lower inflammatory markers
03
May improve physical function
04
May support cognition

Protocol

Amount
20 mg/kg bodyweight
Frequency
Once daily for 2 consecutive days per month
When
With a meal containing fat to improve absorption.

Onset Time

After 2-3 monthly pulses (8-12 weeks); acute effects are not established.

Who Should Consider

Adults 50+ interested in experimental longevity
People willing to track biomarkers
Participants in supervised senolytic protocols

How It Works

Fisetin appears to reduce senescent-cell survival by shifting BCL-2 family signaling toward apoptosis and may suppress SASP cytokine output. It also inhibits NF-κB and other pro-inflammatory pathways, which is why it is being studied as a senolytic and anti-inflammatory compound.

Updated 5/19/2026

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